• Issue

    Pharmacology Research & Perspectives: Volume 6, Issue 6

    December 2018
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ISSUE INFORMATION

Open Access

Issue Information

  • First Published: 25 October 2018

ORIGINAL ARTICLES

Open Access

Polypharmacy and medication deprescribing: A survey among multimorbid older adults in Denmark

Michaela L. Schiøtz,  Anne Frølich,  Anette K. Jensen,  Lene Reuther,  Hans Perrild,  Tonny S. Petersen,  Jonatan Kornholt,  Mikkel B. Christensen, 
  • First Published: 23 October 2018
Open Access

The role of loops B and C in determining the potentiation of GABAA receptors by midazolam

Olivia A. Moody,  Andrew Jenkins, 
  • First Published: 13 November 2018
Open Access

Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability

Donna W. Lee,  Shelly Zhong,  Rama Pai,  Julie Rae,  Siddharth Sukumaran,  Eric G. Stefanich,  Jeff Lutman,  Estelle Doudement,  Xiaoting Wang,  Brandon Harder,  Annemarie Lekkerkerker,  Ann Herman,  Wenjun Ouyang,  Dimitry M. Danilenko, 
  • First Published: 15 November 2018
Open Access

Natural language processing-based assessment of consistency in summaries of product characteristics of generic antimicrobials

Rumiko Shimazawa,  Yoshinobu Kano,  Masayuki Ikeda, 
  • First Published: 11 November 2018
Open Access

Pharmacokinetics and safety of Enasidenib following single oral doses in Japanese and Caucasian subjects

Yan Li,  Liangang Liu,  Diana Gomez,  Jian Chen,  Zeen Tong,  Maria Palmisano,  Simon Zhou, 
  • First Published: 23 October 2018
Open Access

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain

Yaping Hua,  Waqas Azeem,  Yunheng Shen,  Shoude Zhang,  Jan R. Olsen,  Anne M. Øyan,  Xisong Ke,  Weidong Zhang,  Karl-Henning Kalland, 
  • First Published: 05 November 2018
Open Access

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

Melanie Wannick,  Siegfried Bezdek,  Nathalie Guillen,  Markus Thieme,  Fibi Meshrkey,  Sadegh Mousavi,  Michaela Seeling,  Falk Nimmerjahn,  Attila Mócsai,  Detlef Zillikens,  Tanya Sezin,  Christian D. Sadik, 
  • First Published: 08 November 2018
Open Access

Onset timing of statin-induced musculoskeletal adverse events and concomitant drug-associated shift in onset timing of MAEs

Hayato Akimoto,  Akio Negishi,  Shinji Oshima,  Mitsuyoshi Okita,  Sachihiko Numajiri,  Naoko Inoue,  Shigeru Ohshima,  Daisuke Kobayashi, 
  • First Published: 07 November 2018
Open Access

Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery

Mizuho Asada,  Masashi Nagata,  Tomohiro Mizuno,  Tokujiro Uchida,  Naoki Kurashima,  Hiromitsu Takahashi,  Koshi Makita,  Hirokuni Arai,  Hirotoshi Echizen,  Masato Yasuhara, 
  • First Published: 05 November 2018
Open Access

Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region

Naofumi Seira,  Kazuyuki Yamagata,  Keijo Fukushima,  Yumi Araki,  Naoki Kurata,  Naoki Yanagisawa,  Masato Mashimo,  Hiroyuki Nakamura,  John W. Regan,  Toshihiko Murayama,  Hiromichi Fujino, 
  • First Published: 11 November 2018
Open Access

Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model

Vishnu Chintalgattu,  Joanne Greenberg,  Shivani Singh,  Venice Chiueh,  Amy Gilbert,  Jason W. O'Neill,  Stephen Smith,  Simon Jackson,  Aarif Y. Khakoo,  TaeWeon Lee, 
  • First Published: 14 November 2018
Open Access

Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model

Thomas Christoph,  Robert Raffa,  Jean De Vry,  Wolfgang Schröder, 
  • First Published: 28 November 2018
Open Access

Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies

Chiara Ruzza,  Federica Ferrari,  Remo Guerrini,  Erika Marzola,  Delia Preti,  Rainer K. Reinscheid,  Girolamo Calo, 
  • First Published: 03 December 2018
Open Access

A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

Sarah Donald,  Mark Elliott,  Bryony Gray,  Fraser Hornby,  Agnieszka Lewandowska,  Sandra Marlin,  Christine Favre-Guilmard,  Cindy Périer,  Sylvie Cornet,  Mikhail Kalinichev,  Johannes Krupp,  Elena Fonfria, 
  • First Published: 22 November 2018
Open Access

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Agnès Poirier,  Marla Weetall,  Katja Heinig,  Franz Bucheli,  Kerstin Schoenlein,  Jochem Alsenz,  Simon Bassett,  Mohammed Ullah,  Claudia Senn,  Hasane Ratni,  Nikolai Naryshkin,  Sergey Paushkin,  Lutz Mueller, 
  • First Published: 29 November 2018
Open Access

Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys

Eriko Suzuki,  Naoko Nishimura,  Tetsuya Yoshikawa,  Yudai Kunikiyo,  Keiko Hasegawa,  Keiji Hasumi, 
  • First Published: 05 December 2018