The British Journal of Pharmacology, an official journal of the British Pharmacological Society, is the leading international general pharmacology journal publishing topical pharmacology issues. The BJP is home to the Concise Guide to Pharmacology – an authoritative overview of drug targets and ligands, presenting data from the BPS/IUPHAR Guide to Pharmacology database.

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RESEARCH ARTICLE

Voltage tunes mGlu5 receptor function, impacting synaptic transmission

  •  18 February 2024

Graphical Abstract

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The mGlu5 receptor function is optimal at resting cell potential. Membrane depolarization stabilizes an inactive-like conformation of mGlu5 receptor and decreases agonist-induced Gq protein activation, Ca2+ release from intracellular stores and gating of NMDA and TRPC6 channels.

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