Volume 27, Issue 5 p. 607-611
Free Access

Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis.

SJ Preston

SJ Preston

Florance and Cope Professorial Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

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MH Arnold

MH Arnold

Florance and Cope Professorial Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

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EM Beller

EM Beller

Florance and Cope Professorial Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

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PM Brooks

PM Brooks

Florance and Cope Professorial Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

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WW Buchanan

WW Buchanan

Florance and Cope Professorial Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

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First published: May 1989
Citations: 58

Abstract

1. Enteric coated sodium salicylate 4.8 g daily was compared with the same dose of enteric coated aspirin in 18 patients with rheumatoid arthritis. 2. After an initial washout period lasting 3 days, patients were randomly allocated to treatment with sodium salicylate or aspirin. After 2 weeks the two treatments were crossed over. 3. Pain relief, reduction in articular index of joint tenderness, increase in grip strength, decrease in digital joint circumference and patients' assessment showed significant improvement with both treatments compared with the washout period. No significant differences were found between the two therapies. 4. No correlation was found in the degree of improvement in any of the clinical outcomes and the salicylate concentrations at steady state.