Volume 111, Issue 1 p. 1-3
Free Access

Natriuretic action of angiotensin(1–7)

AnnMarie DelliPizzi

AnnMarie DelliPizzi

Department of Pharmacology, New York Medical College, Valhalla, New York 10595

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Sean D. Hilchey

Sean D. Hilchey

Department of Pharmacology, New York Medical College, Valhalla, New York 10595

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Caroline P. Bell-Quilley

Corresponding Author

Caroline P. Bell-Quilley

Department of Pharmacology, New York Medical College, Valhalla, New York 10595

Department of Pharmacology, New York Medical College, Valhalla, New York 10595Search for more papers by this author
First published: January 1994
Citations: 125

Abstract

Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin-angiotensin system.