Volume 107, Issue 3 p. 660-664

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The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

F.Q. Cunha,

F.Q. Cunha

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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S. Poole,

Corresponding Author

S. Poole

Division of Endocrinology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG

Division of Endocrinology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QGSearch for more papers by this author

B.B. Lorenzetti,

B.B. Lorenzetti

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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S.H. Ferreira,

S.H. Ferreira

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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F.Q. Cunha,

F.Q. Cunha

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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S. Poole,

Corresponding Author

S. Poole

Division of Endocrinology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QG

Division of Endocrinology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts EN6 3QGSearch for more papers by this author

B.B. Lorenzetti,

B.B. Lorenzetti

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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S.H. Ferreira,

S.H. Ferreira

Department of Pharmacology, Faculty of Medicine, 14049 Ribeirao Preto, Sao Paulo, Brazil

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First published: November 1992

https://doi.org/10.1111/j.1476-5381.1992.tb14503.x

Citations: 675

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Abstract

1
The hyperalgesic activities in rats of interleukin-1β (IL-1β), IL-6, IL-8, tumour necrosis factor α (TNFα) and carrageenin were investigated.
2
IL-6 activated the previously delineated IL-1/prostaglandin hyperalgesic pathway but not the IL-8/sympathetic mediated hyperalgesic pathway.
3
TNFα and carrageenin activated both pathways.
4
Antiserum neutralizing endogenous TNFα abolished the response to carrageenin whereas antisera neutralizing endogenous IL-1β, IL-6 and IL-8 each partially inhibited the response.
5
The combination of antisera neutralizing endogenous IL-1β + IL-8 or IL-6 + IL-8 abolished the response to carrageenin.
6
These results show that TNFα has an early and crucial role in the development of inflammatory hyperaglesia.
7
The delineation of the roles of TNFα, IL-1β, IL-6 and IL-8 in the development of inflammatory hyperalgesia taken together with the finding that the production of these cytokines is inhibited by steroidal anti-inflammatory drugs provides a mechanism of action for these drugs in the treatment of inflammatory hyperalgesia.

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Volume107, Issue3

November 1992

Pages 660-664

The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

Abstract

References

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The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia

Abstract

References

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