Volume 43, Issue 4 p. 429-433
Free Access

Use of sumatriptan in Denmark in 1994–5: an epidemiological analysisof nationwide prescription data

David Gaist

David Gaist

Department of Clinical Pharmacology, IMB, Odense University, Odense and ,

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Morten Andersen

Morten Andersen

Department of Clinical Pharmacology, IMB, Odense University, Odense and ,

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Ann-Lisbeth Aarup

Ann-Lisbeth Aarup

Medicines Division, National Board of Health, Copenhagen, Denmark

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Jesper Hallas

Jesper Hallas

Department of Clinical Pharmacology, IMB, Odense University, Odense and ,

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Lars Freng Gram

Lars Freng Gram

Department of Clinical Pharmacology, IMB, Odense University, Odense and ,

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First published: 02 October 2003
Citations: 37
Dr David Gaist Department of Clinical Pharmacology, Institute of Medical Biology, Odense University, Winsløwparken 19 III, DK-5000 Odense C, Denmark.

Abstract

Aims We describe the use of medication with symptomatic relief of migraine as specific indication by analysing prescription data from the entire Danish population in 1994 and 1995.

Methods The data for sumatriptan were analysed at the level of the individual user. We used aggregated data for ergotamine drugs.

Results Sumatriptan constituted 46% of the total amount of defined daily doses (DDD) sold and 94% of the total pharmacy retail price expenses in the drug-group studied. In total, 43 389 users of sumatriptan were identified who presented 340 148 prescriptions, corresponding to 2.2 million DDD of sumatriptan. The quarterly consumption increased by 50% during the study period. Tablets accounted for 92% of consumption. The 1 year period prevalence of use of sumatriptan among persons 16 years and older was 7.8 per 1000 in 1995 with a female to male prevalence ratio of 3.8:1. Use was most common in the age interval 35–54 years. Regional differences in use, which were not large, were positively correlated to the degree of urbanization. The incidence of use of sumatriptan was estimated at 3.6 per 1000 person-years. The intensity of use of sumatriptan varied greatly with 1.1% of patients (n=507) using 60 DDD or more within 30 days at some time during the observation period. Long-term high use of tablets was common in this group.

Conclusions We conclude that sumatriptan had a considerable impact on the treatment of migraine with prescription drugs in Denmark. The underlying reasons for high use of the drug in a smaller fraction of the patients deserve further study.