Measuring the impact of medicines regulatory interventions – Systematic review and methodological considerations
Thomas Goedecke, Daniel R. Morales, Alexandra Pacurariu, Xavier Kurz

Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials
Kannan Sridharan, Gowri Sivaramakrishnan

Adverse effects of a single dose of gentamicin in adults: a systematic reviewbr />Rachel S. Hayward, Jan Harding, Rob Molloy, Lucy Land, Kate Longcroft‐Neal, David Moore, Jonathan D. C. Ross

Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis
Stefanos Bonovas, Georgios K. Nikolopoulos, Theodore Lytras, Gionata Fiorino, Laurent Peyrin‐Biroulet, Silvio Danese

Optimal dosing and delivery of parathyroid hormone and its analogues for osteoporosis and hypoparathyroidism – translating the pharmacology
Donovan Tay, Serge Cremers, John P. Bilezikian

Renal function monitoring in heart failure – what is the optimal frequency? A narrative review
Ahmed Al‐Naher, David Wright, Mark Alexander John Devonald, Munir Pirmohamed


Renal toxicity and chemotherapy in children with cancer
Antonio Ruggiero, Pietro Ferrara, Giorgio Attinà, Daniela Rizzo, Riccardo Riccardi

Unlicensed and off-label uses of medicines: definitions and clarification of terminology
Jeffrey K. Aronson, Robin E. Ferner

Initial anticoagulation in patients with pulmonary embolism: thrombolysis, unfractionated heparin, LMWH, fondaparinux, or DOACs?
Jenneke Leentjens, Mike Peters, Anne C. Esselink, Yvo Smulders, Cornelis Kramers

Comparison of effect sizes between enriched and nonenriched trials of analgesics for chronic musculoskeletal pain: a systematic review
Tie P. Yamato, Chris G. Maher, Bruno T. Saragiotto, Christina Abdel Shaheed, Anne M. Moseley, Chung‐Wei Christine Lin, Bart Koes, Andrew J. McLachlan

Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies
Shan‐Yan Gao, Qi‐Jun Wu, Tie‐Ning Zhang, Zi‐Qi Shen, Cai‐Xia Liu, Xin Xu, Chao Ji, Yu‐Hong Zhao

Aprepitant and fosaprepitant drug interactions: a systematic review
Priya Patel, J. Steven Leeder, Micheline Piquette‐Miller, L. Lee Dupuis

Risk factors of adverse health outcomes after hospital discharge modifiable by clinical pharmacist interventions: a review with a systematic approach
Benedict Morath, Tanja Mayer, Alexander Francesco Josef Send, Torsten Hoppe‐Tichy, Walter Emil Haefeli, Hanna Marita Seidling

Pharmacogenomics of off-target adverse drug reactions
Sarah L. Garon, Rebecca K. Pavlos, Katie D. White, Nancy J. Brown, Cosby A. Stone Jr, Elizabeth J. Phillips

Electronic case report forms and electronic data capture within clinical trials and pharmacoepidemiology
David A. Rorie, Robert W. V. Flynn, Kerr Grieve, Alexander Doney, Isla Mackenzie, Thomas M. MacDonald, Amy Rogers

Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta-analysis
Alberto Tringali, Raffaele Manta, Mariano Sica, Gabrio Bassotti, Riccardo Marmo, Massimiliano Mutignani

Efficacy of olanzapine for the prophylaxis of chemotherapy-induced nausea and vomiting: a meta-analysis
Ting Yang, Qianxin Liu, Min Lu, Lingyue Ma, Ying Zhou, Yimin Cui

Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis
Eva Dolezelova, Evan Stein, Giuseppe Derosa, Pamela Maffioli, Petr Nachtigal, Amirhossein Sahebkar

The impact of olodaterol on the risk of mortality and serious adverse events: a systematic review and meta-analysis
Hyun Woo Lee, Hyung‐Jun Kim, Chang‐Hoon Lee

Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1)
Hannah H. Lee and Richard H. Ho

Is there potential for therapeutic drug monitoring of biologic agents in rheumatoid arthritis?
Carla Bastida, Virginia Ruíz, Mariona Pascal, Jordi Yagüe, Raimon Sanmartí and Dolors Soy

Impact of concomitant medications on obstructive sleep apnoea
Ingrid Jullian‐Desayes, Bruno Revol, Elisa Chareyre, Philippe Camus, Céline Villier, Jean‐Christian Borel, Jean‐Louis Pepin and Marie Joyeux‐Faure

Prevention of cardiotoxicity among survivors of childhood cancer
Kelley K. Hutchins, Hani Siddeek, Vivian I. Franco and Steven E. Lipshultz

Understanding and applying pharmacometric modelling and simulation in clinical practice and research
Joseph F. Standing

Microtubule destabilising agents: far more than just antimitotic anticancer drugs
Darcy Bates and Alan Eastman

Managing drug–drug interactions with new direct-acting antiviral agents in chronic hepatitis C
Sarah Talavera Pons, Anne Boyer, Geraldine Lamblin, Philip Chennell, François‐Thibault Châtenet, Carine Nicolas, Valérie Sautou and Armand Abergel

A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients
Evelien J. M. Kuip, Maarten L. Zandvliet, Stijn L. W. Koolen, Ron H. J. Mathijssen and Carin C. D. van der Rijt

Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review
Shaun Wen Huey Lee, Nai Ming Lai, Nathorn Chaiyakunapruk and David Weng Kwai Chong

Systematic review and meta-analysis of clinical outcomes of early caffeine therapy in preterm neonates
Kok Pim Kua and Shaun Wen Huey Lee

Optimizing identification and management of COPD patients – reviewing the role of the community pharmacist
Thys van der Molen, Job F. M. van Boven, Terence Maguire, Pankaj Goyal and Pablo Altman


Systematic review of published Phase 3 data on anti-PCSK9 monoclonal antibodies in patients with hypercholesterolaemia
Ioanna Gouni-Berthold, Olivier S. Descamps, Uwe Fraass, Elizabeth Hartfield, Kim Allcott, Ricardo Dent and Winfried März

Clinical trials for authorized biosimilars in the European Union: a systematic review
Johanna Mielke, Bernd Jilma, Franz Koenig and Byron Jones

A systematic review of tranexamic acid in hip fracture surgery
Luke S. Farrow, Toby O. Smith, George P. Ashcroft and Phyo K. Myint

UK medicines regulation: responding to current challenges
Natalie Richards and Ian Hudson

CYP2C19 and CYP2D6 genotypes in Pacific peoples
Nuala A. Helsby

Design and conduct of early phase drug studies in children: challenges and opportunities
Michael Rieder and Daniel Hawcutt

A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models
Guido van Amerongen, Matthijs W. de Boer, Geert Jan Groeneveld and Justin L. Hay

Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases
Paul Acheampong and Simon H. L. Thomas

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy
Linda Gabrielsson, Sofia Mattsson and Christopher J. Fowler

AKT in cancer: new molecular insights and advances in drug development
Prabhjot S. Mundi, Jasgit Sachdev, Carolyn McCourt and Kevin Kalinsky

Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective
Carlo Patrono

The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis
Amy T. Page, Rhonda M. Clifford, Kathleen Potter, Darren Schwartz and Christopher D. Etherton-Beer

Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis
Zheng-he Yu, Hai-yin Jiang, Li Shao, Yuan-yue Zhou, Hai-yan Shi and Bing Ruan

Direct oral anticoagulants for stroke prevention in patients with atrial fibrillation: meta-analysis by geographic region with a focus on European patients
Antonio Gómez-Outes, Ana-Isabel Terleira-Fernández, Gonzalo Calvo-Rojas, M. Luisa Suárez-Gea and Emilio Vargas-Castrillón

The medication reconciliation process and classification of discrepancies: a systematic review
Enas Almanasreh, Rebekah Moles and Timothy F. Chen

Therapeutic nucleic acids: current clinical status
Kannan Sridharan and Nithya Jaideep Gogtay

Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo
Georges Vauquelin

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity
Folefac Aminkeng, Colin J. D. Ross, Shahrad R. Rassekh, Soomi Hwang, Michael J. Rieder, Amit P. Bhavsar, Anne Smith, Shubhayan Sanatani, Karen A. Gelmon, Daniel Bernstein, Michael R. Hayden, Ursula Amstutz, Bruce C. Carleton and CPNDS Clinical Practice Recommendations Group

Hypoglycaemia when Adding Sulphonylurea to Metformin: A Systematic Review and Network Meta-analysis
S. E. Andersen and M. Christensenfeasabilit

Injection site reactions after subcutaneous oligonucleotide therapy
Leonie van Meer, Matthijs Moerland, Jolie Gallagher, Martijn B. A. van Doorn, Errol P. Prens, Adam F. Cohen, Robert Rissmann and Jacobus Burggraaf

The great ESCAPE – a clinical pharmacologist's journey in stroke research
David J. P. Williams

Drug-induced Raynaud's phenomenon: beyond β-adrenoceptor blockers
Charles Khouri, Sophie Blaise, Patrick Carpentier, Céline Villier, Jean-Luc Cracowski and Matthieu Roustit

Adverse drug event reporting systems: a systematic review
Chantelle Bailey, David Peddie, Maeve E. Wickham, Katherin Badke, Serena S. Small, Mary M. Doyle-Waters, Ellen Balka and Corinne M. Hohl

Japanese regulation of biosimilar products: past experience and current challenges
Teruyo Arato

N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review
Mohamed Farouk Chughlay, Nicole Kramer, C. Wendy Spearman, Mahmoud Werfalli and Karen Cohen

Mechanism of isoniazid-induced hepatotoxicity: then and now
Imir Metushi, Jack Uetrecht and Elizabeth Phillips

Statin therapy and plasma free fatty acids: a systematic review and meta-analysis of controlled clinical trials
Amirhossein Sahebkar, Luis E. Simental-Mendía, Claudio Pedone, Gianna Ferretti, Petr Nachtigal, Simona Bo, Giuseppe Derosa, Pamela Maffioli and Gerald F. Watts

Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: a systematic review and meta-analysis
Giuseppe Derosa, Pamela Maffioli and Amirhossein Sahebkar

Review of commonly used age-based weight estimates for paediatric drug dosing in relation to the pharmacokinetic properties of resuscitation drugs
Clare Francesca Carasco, Penny Fletcher and Ian Maconochie

The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis
Anick Bérard, Noha Iessa, Sonia Chaabane, Flory T. Muanda, Takoua Boukhris and Jin-Ping Zhao

Can Paracetamol (Acetaminophen) Be Administered To Patients With Liver Impairment?
Kelly L. Hayward, Elizabeth E. Powell, Katharine M. Irvine and Jennifer H. Martin

Achieving The World Health Organization's Vision For Clinical Pharmacology
Jennifer H. Martin, David Henry, Jean Gray, Richard Day, Felix Bochner, Albert Ferro, Munir Pirmohamed, Klaus Mörike and Matthias Schwab

Repurposing Some Older Drugs That Cross The Blood-Brain Barrier And Have Potential Anticancer Activity To Provide New Treatment Options For Glioblastoma
Dayle Rundle-Thiele, Richard Head, Leah Cosgrove and Jennifer H. Martin

Cato Guldberg And Peter Waage, The History Of The Law Of Mass Action, And Its Relevance To Clinical Pharmacology
Robin E. Ferner and Jeffrey K. Aronson

Glucagon-Like Peptide-1(GLP-1) Receptor Agonists: Potential To Reduce Fracture Risk In Diabetic Patients?
Guojing Luo, Hong Liu and Hongyun Lu

Efficacy And Safety Of Silodosin In The Medical Expulsion Therapy For Distal Ureteral Calculi: A Systematic Review And Meta-Analysis
Wei Huang, Peng Xue, Huantao Zong, and Yong Zhang

The Law Of Mass Action And The Pharmacological Concentration-Effect Curve:Resolving The Paradox Of Apparently Non-Dose-Related Adverse Drug Reactions
Jeffrey K. Aronson and Robin E. Ferner

Does Celecoxib Improve The Efficacy Of Chemotherapy For Advanced Non-Smallcell Lung Cancer?
Leng-Chen Hou, Fang Huang and Hong-Bin Xu

Incidence And Risk Of Severe Infections Associated With Aflibercept In Cancer Patients: A Systematic Review And Meta-Analysis
Xi Zhang, Yuge Ran, Yongjie Shao, Kunjie Wang and Yuanxue Zhu

Treating Disorders Of The Neonatal Central Nervous System: Pharmacokineticand Pharmacodynamic Considerations With A Focus On Antiepileptics
Maria D. Donovan, Geraldine B. Boylan, Deirdre M. Murray, John F. Cryan and Brendan T. Griffin

The Mass Action Equation In Pharmacology
Terry Kenakin