Browse Editor’s Choice

Editors Choice articles are picked out as being of particular interest to British Journal of Pharmacology readers

Composite endpoints and the distortion of risk–benefit analysis

Many trials lack power to detect effects of an intervention on a single endpoint and because of this, combined endpoints have been invented. These generally combine related events. For instance, a medicine preventing death from cardiovascular cause or myocardial infarction or heart failure may be effective.... more

Translating QT interval prolongation from conscious dogs to humans

The so called thorough QT study became fashionable after a number of well publicised withdrawals of drugs because of torsades-des-pointes ventricular tachycardia caused by QT prolongation. These studies in humans were extremely costly and yielded relatively little in the sense of increased patient safety..... more