Browse Editor’s Choice

Editors Choice articles are picked out as being of particular interest to British Journal of Pharmacology readers

Pharmacogenomics of off-target adverse drug reactions

There are still medical students who are taught that some side effects of drugs are idiosyncratic. When this fine example of fake news is brought to them they nod and think they have learned something. ἰδιοσυγκρασία unfortunately means no more than ‘a particular habit’. In other words the side effect.... more

Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers

How can you find out if an analgesic works in humans? Clearly by observing if it reduces pain. Unfortunately when a patient has a painful condition or undergoes a painful procedure there is not much time to investigate this for ethical reasons. There are effective analgesics and they have to be administered. Therefore.... more

Composite endpoints and the distortion of risk–benefit analysis

Many trials lack power to detect effects of an intervention on a single endpoint and because of this, combined endpoints have been invented. These generally combine related events. For instance, a medicine preventing death from cardiovascular cause or myocardial infarction or heart failure may be effective.... more

Translating QT interval prolongation from conscious dogs to humans

The so called thorough QT study became fashionable after a number of well publicised withdrawals of drugs because of torsades-des-pointes ventricular tachycardia caused by QT prolongation. These studies in humans were extremely costly and yielded relatively little in the sense of increased patient safety..... more