Pharmacological hypothesis: Nitric oxide-induced inhibition of ADAM-17 activity as well as vesicle release can in turn prevent the production of soluble endothelin-converting enzyme
Sanjaya Kuruppu, Niwanthi W. Rajapakse, Helena C. Parkington, Ian Smith

Ethics of animal research in human disease remediation, its institutional teaching; and alternatives to animal experimentation
Rajkumar Cheluvappa, Paul Scowen, Rajaraman Eri

Self-medication misuse in the Middle East: a systematic literature review
Malak M. Khalifeh, Nicholas D. Moore, Pascale R. Salameh

Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases
Md. Abdul Alim Al-Bari

Effects of resveratrol on drug- and carcinogen-metabolizing enzymes, implications for cancer prevention
Ariane R. Guthrie, H-H. Sherry Chow and Jessica A. Martinez


Pharmacokinetics and pharmacodynamics of antibiotics in critically ill acute kidney injury patients
Welder Zamoner, Fernanda M. de Freitas, Durval S. S. Garms, Mariele Gobo de Oliveira, André L. Balbi and Daniela Ponce

Mitochondrial fission – a drug target for cytoprotection or cytodestruction?
Ayeshah A. Rosdah, Jessica K. Holien, Lea M. D. Delbridge, Gregory J. Dusting and Shiang Y. Lim

Anti-inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
Vitor Caiaffo, Belisa D. R. Oliveira, Fabrício B. de Sá and Joaquim Evêncio Neto

Preclinical animal anxiety research – flaws and prejudices
Abdelkader Ennaceur and Paul L. Chazot

Mechanisms of the gabapentinoids and α2δ-1 calcium channel subunit in neuropathic pain
Ryan Patel and Anthony H. Dickenson

Role of endoplasmic reticulum stress in drug-induced toxicity
Fabienne Foufelle and Bernard Fromenty


Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist
Rachel Garner, Shobha Gopalakrishnan, John A. McCauley, Rodney A. Bednar, Stanley L. Gaul, Scott D. Mosser, Laszlo Kiss, Joseph J. Lynch, Shil Patel, Christine Fand ozzi, Armando Lagrutta, Richard Briscoe, Nigel J. Liverton, Blake M. Paterson, James J. Vornov and Reza Mazhari

Pharmacological implications of the Ca2 /cAMP signaling interaction: from risk for antihypertensive therapy to potential beneficial for neurological and psychiatric disorders
Afonso Caricati-Neto, Antonio G. García and Leandro Bueno Bergantin

Pharmacology and physiology of gastrointestinal enteroendocrine cells
O. J. Mace, B. Tehan and F. Marshall

Analysis of drug combinations: current methodological landscape
Julie Foucquier and Mickael Guedj

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action
Patrício Soares-da-Silva, Nuno Pires, Maria João Bonifácio, Ana I. Loureiro, Nuno Palma and Lyndon C. Wright

In Memoriam: Darrell R. Abernethy, M.D. Ph.D.

It is with deep sadness that the Editorial Team at PR&P must convey the news that Darrell Abernethy, Editor in Chief of the Journal, has recently passed away. Darrell has been instrumental in raising the profile and quality of PR&P in both his roles on the Journal, first as Deputy Editor and then Editor. He has been a true inspiration to so many of our authors and editors who work in the field of pharmacology, very much a team player, providing considered and thoughtful responses. His wise counsel will be missed.

Rest in peace

PR&P Editorial Team

Darrell's obituary can be viewed on the ASPET website