Rachel A. Wood, Mark J. Barbour, Gwyn W. Gould, Margaret R. Cunningham, Robin J. Plevin
Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents
Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Haruhide Kimura
Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties
Luca Piali, Magdalena Birker‐Robaczewska, Cyrille Lescop, Sylvie Froidevaux, Nicole Schmitz, Keith Morrison, Christopher Kohl, Markus Rey, Rolf Studer, Enrico Vezzali, et al.
Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers
Kathleen Weisel, Nicola E. Scott, Debra J. Tompson, Bartholomew J. Votta, Sujith Madhavan, Kat Povey, Allen Wolstenholme, Monica Simeoni, Todd Rudo, Lauren Richards‐Peterson, et al.
Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease
Daniel S. Whittaker, Huei‐Bin Wang, Dawn H. Loh, Roger Cachope, Christopher S. Colwell.
An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model
Xiaoyan Zhou, Ji Zhang, Robin Haimbach, Wei Zhu, Rosemary Mayer‐Ezell, Margarita Garcia‐Calvo, Elizabeth Smith, Olga Price, Yanqing Kan, Emanuel Zycband, et al.
In vitro pharmacological characterization of a novel unbiased NOP receptor-selective nonpeptide agonist AT-403
Federica Ferrari, Davide Malfacini, Blair V. Journigan, Mark F. Bird, Claudio Trapella,Remo Guerrini, David G. Lambert, Girolamo Calo,& Nurulain T. Zaveri.
KCTD12 modulation of GABA (B) receptor function
Melody Li, Carol J. Milligan, Haiyan Wang, Andrew Walker, Leonid Churilov,Andrew J. Lawrence, Christopher A. Reid, Seth C. Hopkins & Steven Petrou.
Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists
Srinivasan Chandrasekhar,Xiao-Peng Yu, Anita K. Harvey, Jennifer L. Oskins, Chaohua Lin,Xushan Wang, Maria-Jesus Blanco, Matthew J. Fisher, Steven L. Kuklish, Matthew A. Schiffler, Tatiana Vetman, Alan M. Warshawsky, Jeremy S. York, Alison M. Bendele & Mark G. Chambers
Chronic treatment of (R)-α-lipoic acid reduces blood glucose and lipid levels in high-fat diet and low-dose streptozotocin-induced metabolic syndrome and type 2 diabetes in Sprague-Dawley rats
Hardik Ghelani, Valentina Razmovski-Naumovski, & Srinivas Nammi
GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity
Emmanuel Sturchler, Xia Li, Maria de Lourdes Ladino, Kasia Kaczanowska, Michael Cameron, Patrick R. Griffin, M. G. Finn, Athina Markou & Patricia McDonald
Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog
Andrea Brancale, Kunwar Shailubhai, Salvatore Ferla, Antonio Ricci, Marcella Bassetto & Gary S Jacob
Acute cocaine exposure elicits rises in calcium in arousal-related laterodorsal tegmental neurons
Mads Ødum Lambert, Theis Højland Ipsen & Kristi Anne Kohlmeier
Genome-wide DNA methylation profiling of CpG islands in a morpholino anthracycline derivative-resistant leukemia cell line: p38[alpha] as a novel candidate for resistance
Takeshi Asano, Hidehiko Narazaki, Atsushi Fujita
Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors
Jeffrey M. Witkin, Linda M. Rorick‐Kehn, Mark J. Benvenga, Benjamin L. Adams, Scott D. Gleason, Karen M. Knitowski, Xia Li, Steven Chaney, Julie F. Falcone, Janice W. Smith, et al
Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation
Verena Gotta, Zhiyi Yu, Frank Cools, Karel van Ammel, David J. Gallacher, Sandra A. G. Visser, Frederick Sannajust, Pierre Morissette, Meindert Danhof, Piet H. van der Graaf
RGS14 regulates the lifetime of G[alpha]-GTP signaling but does not prolong Gβ[gamma] signaling following receptor activation in live cells
Nicole E. Brown, Nevin A. Lambert, John R. Hepler
Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells
Mark Soave, Leigh A. Stoddart, Alastair Brown, Jeanette Woolard, Stephen J. Hill
Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target
Wendy Ankrom, Harold B. Wood, Jiayi Xu, Wayne Geissler, Tom Bateman, Manash S. Chatterjee, Kung‐I Feng, Joseph M. Metzger, Walter R. Strapps, Marija Tadin‐Strapps, et al
Anti-inflammatory effects of the novel inhaled phosphodiesterase type 4 inhibitor CHF6001 on virus-inducible cytokines
Michael R. Edwards, Fabrizio Facchinetti, Maurizio Civelli, Gino Villetti, Sebastian L. Johnston
miRNA-27b levels are associated with CYP3A activity in vitro and in vivo
Lena Ekström, Ilona Skilving, Marie‐Louise Ovesjö, Eleni Aklillu, Hanna Nylén, Anders Rane, Ulf Diczfalusy, Linda Björkhem‐Bergman
Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression
Fionn E. O'Brien, Gerard M. Moloney, Karen A. Scott, Richard M. O'Connor, Gerard Clarke, Timothy G. Dinan, Brendan T. Griffin, John F. Cryan
β1 Adrenoceptor antagonistic effects of the supposedly selective β2 adrenoceptor antagonist ICI 118,551 on the positive inotropic effect of adrenaline in murine hearts
Simon Pecha, Frederik Flenner, Klaus‐Dieter Söhren, Kristina Lorenz, Thomas Eschenhagen, Torsten Christ
Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats
Hoi‐Kei Lon, Debra C. DuBois, Justin C. Earp, Richard R. Almon, William J. Jusko
Pharmacology and physiology of gastrointestinal enteroendocrine cells
O. J. Mace, B. Tehan, F. Marshall
Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates
Yihui Shi, Amanda S. Joyner, William Shadrick, Gustavo Palacios, Chandraiah Lagisetti, Philip M. Potter, Lidia C. Sambucetti, Stefan Stamm, Thomas R. Webb
Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation
Marek Lenarczyk, Jidong Su, Steven T. Haworth, Richard Komorowski, Brian L. Fish, Raymond Q. Migrino, Leanne Harmann, John W. Hopewell, Amy Kronenberg, Shailendra Patel, et al
A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory impairment
Irina Korshunova, Michelle D. Gjørlund, Sylwia Owczarek, Anders V. Petersen, Jean‐François Perrier, Casper René Gøtzsche, Vladimir Berezin
Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis
Laura Conde de la Rosa, Titia E. Vrenken, Manon Buist‐Homan, Klaas Nico Faber, Han Moshage
Functional desensitization of the β2 adrenoceptor is not dependent on agonist efficacy
Elizabeth M. Rosethorne, Michelle E. Bradley, Toby C. Kent, Steven J. Charlton
Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes
Yusheng Qu, Mei Fang, BaoXi Gao, Shanti Amagasu, William J. Crumb, Hugo M. Vargas
In Memoriam: Darrell R. Abernethy, M.D. Ph.D.
It is with deep sadness that the Editorial Team at PR&P must convey the news that Darrell Abernethy, Editor in Chief of the Journal, has recently passed away. Darrell has been instrumental in raising the profile and quality of PR&P in both his roles on the Journal, first as Deputy Editor and then Editor. He has been a true inspiration to so many of our authors and editors who work in the field of pharmacology, very much a team player, providing considered and thoughtful responses. His wise counsel will be missed.
Rest in peace
PR&P Editorial Team
Darrell's obituary can be viewed on the ASPET website